Acuity reduced Therapy group Latanoprost/timolol fixeddose combination (n=56) 23 12 (21.4) 1 (1.eight) 8 (14.three) three (five.4) 12 (21.four) 1 (1.eight) 2 (three.six) 0 0 3 (five.4) 4 (7.1) 4 (7.1) two (3.six) 1 (1.eight) 2 (3.six) 0 2 (three.6) two (three.6) 0 Latanoprost + timolol (n=58) 14 10 (17.2) two (three.four) 5 (eight.six) 3 (5.two) 10 (17.2) 3 (5.2) 0 0 0 1 (1.7) six (10.three) 2 (three.4) 1 (1.7) 1 (1.7) 0 0 0 0 0 Latanoprost (n=55) 15 8 (14.five) 0 three (five.five) five (9.1) 8 (14.5) 0 two (3.six) 1 (1.eight) 0 1 (1.eight) two (3.six) 2 (three.six) 1 (1.eight) 2 (three.six) 1 (1.eight) 1 (1.8) 0 1 (1.8) 1 (1.eight) Timolol (n=58) 16 9 (15.five) 0 six (ten.three) three (5.two) 9 (15.5) 1 (1.7) 0 0 1 (1.7) 2 (3.4) 5 (8.6) three (5.2) 0 0 1 (1.7) 1 (1.7) 0 0 0 All round (n=227) 68 39 (17.two) 3 (1.3) 22 (9.7) 14 (six.two) 39 (17.two) five (two.two) 4 (1.eight) 1 (0.four) 1 (0.4) 7 (3.1) 17 (7.5) 11 (4.8) 4 (1.eight) four (1.8) four (1.eight) two (0.9) two (0.9) three (1.3) 1 (0.four)Notes: *All ocular TEAEs have been mild or moderate in nature. Patients may well have reported extra than a single event per Method Organ Class or Preferred Term. Individuals had been counted once for each Technique Organ Class or Preferred Term at the maximum intensity/relationship seasoned. Abbreviation: TEAE, treatment-emergent adverse occasion.Clinical Ophthalmology 2014:submit your manuscript | dovepressDovepressBhagat et alDovepressTable four summary of nonocular Teaes reported throughout the course with the study (safety population)Program Organ Class/ Preferred Term Total variety of TEAEs, n Total number of sufferers with no less than a single TEAE, n ( )* Sufferers reporting TEAEs almost certainly associated with therapy, n ( ) Individuals reporting TEAEs possibly related to therapy, n ( ) Sufferers reporting TEAEs unlikely or not associated with remedy, n ( ) Cardiac issues, n ( ) Bradycardia gastrointestinal issues Dyspepsia basic issues and administration web page situations Peripheral edema Pyrexia infections and infestations Amebiasis nasopharyngitis Metabolism and nutrition problems Vitamin B12 deficiency nervous technique problems headache Muscle spasticity Remedy group Latanoprost/timolol fixeddose mixture (n=56) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Latanoprost + timolol (n=58) 1 1 (1.5-Bromo-3-fluoro-2-nitropyridine Purity 7) 0 0 1 (1.1-Methyl-1H-imidazole-4-carbaldehyde uses 7) 0 0 0 0 1 (1.PMID:24120168 7) 1 (1.7) 0 0 0 0 0 0 0 0 0 Latanoprost (n=55) 4 3 (five.five) 0 0 3 (5.5) 0 0 0 0 1 (1.8) 0 1 (1.eight) 0 0 0 1 (1.8) 1 (1.8) 2 (three.6) 1 (1.8) 1 (1.eight) Timolol (n=58) 5 four (6.9) 1 (1.7) 0 3 (five.2) 1 (1.7) 1 (1.7) 1 (1.7) 1 (1.7) 1 (1.7) 0 1 (1.7) 2 (three.four) 1 (1.7) 1 (1.7) 0 0 0 0 0 Overall (n=227) ten eight (three.five) 1 (0.4) 0 7 (3.1) 1 (0.4) 1 (0.4) 1 (0.4) 1 (0.four) 3 (1.3) 1 (0.four) 2 (0.9) two (0.9) 1 (0.4) 1 (0.four) 1 (0.four) 1 (0.four) two (0.9) 1 (0.four) 1 (0.4)Notes: *All nonocular TEAEs have been mild or moderate in nature. Individuals could have reported far more than a single event per Technique Organ Class or Preferred Term. Individuals have been counted after for every Technique Organ Class or Preferred Term in the maximum intensity/relationship skilled. Abbreviation: TEAE, treatment-emergent adverse event.are much more efficacious in reducing IOP than their person elements alone.ten,45 Along with the described potential efficacy benefits of use of fixed-dose combinations in OAG or OHT, such formulations may well facilitate improved adherence and comfort for sufferers. Administration of therapies with simple regimens is important in encouraging long-term use of an effective ocular hypotensive agent that may possibly delay or prevent glaucomatous damage.46 The proof suggests that poor adherence is an challenge in sufferers treated with complicated medication regimens for glaucoma.47-51 This obtaining is supported by research in pati.