Low/negative vs. CIMP-high; MSS vs. MSI-high; BRAF-wildtype vs. BRAF-mutated; DNMT3B-negative vs. DNMT3B-positive). d Models have been adjusted for physique mass index, household history of colorectal cancer in any first-degree relative, regular use of aspirin, physical activity level, alcohol consumption, total caloric intake, and red meat intake.96 Nishihara et al.Table 6. Cumulative Pack-years of Smoking and Incident Colorectal Cancer Risk by Combined Molecular Subtypesa in the Nurses’ Well being Study (1980?008) as well as the Wellness Professionals Follow-up Study (1986?008)By no means Smoker 1?9 HR 95 CI HR 95 CI HR Cumulative Pack-years of Smoking 20?9 95 CI HR 40 95 CI PtrendbCIMP/MSI Subtyping CIMP-low/negative MSS No. Age-adjusted Multivariatec MSI-high No. Age-adjusted Multivariatec CIMP-high MSS No. Age-adjusted Multivariatec MSI-high No. Age-adjusted Multivariatec CIMP-low/negative BRAF-wildtype No. Age-adjusted Multivariate No. Age-adjusted Multivariate CIMP-high BRAF-wildtype No. Age-adjusted Multivariatec BRAF-mutated No. Age-adjusted Multivariatec MSS BRAF-wildtype No. Age-adjusted Multivariatec 1.00 1.00 360 Referent Referent 1.16 1.13 239 0.99, 1.37 0.96, 1.34 1.14 1.10 165 0.95, 1.38 0.91, 1.33 1.20 1.14 142 0.99, 1.46 0.93, 1.40 0.08 0.24 1.00 1.00 43 Referent Referent 0.87 0.86 21 0.52, 1.47 0.51, 1.45 1.45 1.39 22 0.86, two.43 0.82, 2.33 two.44 2.32 36 1.56, three.81 1.48, 3.63 0.0001 0.0001 1.00 1.00 28 Referent Referent 0.81 0.80 12 0.41, 1.60 0.41, 1.59 1.14 1.ten 13 0.59, two.22 0.56, 2.14 1.92 1.83 20 1.07, three.42 1.02, three.27 0.02 0.c c340 1.00 1.00 Referent Referent 19 1.00 1.00 Referent Referent 0.98 0.96 1.18 1.227 0.99, 1.40 0.97, 1.37 ten 0.45, two.11 0.44, 2.07 1.14 1.08 1.20 1.161 0.99, 1.45 0.96, 1.41 eight 0.49, 2.62 0.47, two.48 1.14 1.08 1.22 1.137 1.00, 1.49 0.95, 1.43 six 0.45, two.88 0.43, 2.75 0.72 0.82 0.05 0.29 1.00 1.00 Referent Referent 41 1.00 1.00 Referent Referent 0.98 0.97 0.69 0.11 0.34, 1.39 0.34, 1.37 22 0.58, 1.65 0.57, 1.63 1.90 1.82 0.60 0.7 0.26, 1.38 0.25, 1.33 28 1.17, 3.08 1.12, 2.96 2.85 two.75 1.40 1.14 0.74, two.67 0.68, two.48 42 1.85, four.40 1.78, four.26 0.0001 0.0001 0.42 0.CIMP/BRAF Subtyping341 1.00 1.00 Referent Referent 22 1.00 1.00 Referent Referent 0.65 0.65 1.20 1.232 1.02, 1.42 0.99, 1.39 eight 0.29, 1.48 0.29, 1.47 0.81 0.81 1.21 1.164 1.00, 1.46 0.96, 1.41 six 0.33, two.02 0.32, two.00 1.30 1.27 1.23 1.136 1.00, 1.50 0.95, 1.43 ten 0.60, 2.81 0.59, 2.75 0.49 0.53 0.04 0.BRAF-mutatedMSI/BRAF SubtypingTable continuesAm J Epidemiol. 2013;178(1):84?Smoking Cessation and Colorectal Cancer EpigeneticsTable 6. ContinuedCumulative Pack-years of Smoking Under no circumstances Smoker HR 95 CI HR 1?9 95 CI HR 20?9 95 CI HR 40 95 CI PtrendbBRAF-mutated No.1-(Difluoromethyl)-4-iodo-1H-pyrazole Order Age-adjusted Multivariatec MSI-high BRAF-wildtype No.1020665-73-9 Chemscene Age-adjusted Multivariatec BRAF-mutated No.PMID:23554582 Age-adjusted Multivariatec 1.00 1.00 30 Referent Referent 0.96 0.94 16 0.52, 1.76 0.51, 1.72 1.82 1.74 19 1.02, 3.25 0.97, 3.11 two.94 2.81 31 1.77, four.87 1.69, 4.68 0.0001 0.0001 1.00 1.00 32 Referent Referent 1.04 1.03 18 0.58, 1.86 0.57, 1.83 1.44 1.36 18 0.80, 2.57 0.76, 2.44 1.86 1.79 19 1.04, three.30 1.01, 3.19 0.02 0.03 1.00 1.00 36 Referent Referent 0.70 0.69 14 0.37, 1.30 0.37, 1.28 0.70 0.68 9 0.34, 1.46 0.33, 1.42 1.39 1.33 17 0.77, two.50 0.74, 2.40 0.35 0.Abbreviations: CI, self-confidence interval; CIMP, CpG island methylator phenotype; HR, hazard ratio; MSI, microsatellite instability; MSS, microsatellite steady. a All models were stratified by calendar year of your questionnaire cycle, age, and sex. b Primarily based o.